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Test · Diagnostics

MSI By Sanger Sequencing

Free home sample collection, physician reviewedDaily , Report 7 - 10 DaysReports inBloodSample

The presence of MSI is a sign of DNA mismatch repair deficiency that can be inherited, caused by gem line mutation in MSH2 gene or sporadic due to hypermethylation of MLH1 promoter. Microsatellite instability (MSI)-High indicates a tumor with instability in 30% microsatellite markers. MSI-High occurs in approximately 90% of colorectal cancers from individuals with Lynch syndrome.

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