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Test · Diagnostics

IHC PSMA

Free home sample collection, physician reviewedDaily , Report 5 DaysReports inBloodSample

PSMA, prostate specific membrane antigen, is a Type 2 integral membrane glycoprotein found in prostate and a few other tissues. Three functionally-distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain and prostate specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate cytotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer

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