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Test · Diagnostics

IHC Synaptophysin

Free home sample collection, physician reviewedDaily , Report 5 DaysReports inBloodSample

Synaptophysin is a calcium-binding protein present in the presynaptic vesicles of neurons as well as vesicles in the neuroendocrine cells. Synaptophysin is expressed in neuronal tumors and tumors with neuroendocrine differentiation, including neuroblastoma, ganglioneuroblastoma, ganglioneuroma, pheochromocytoma/paraganglioma and carcinoid/neuroendocrine carcinoma. Antibodies to synaptophysin strongly stain the cytoplasm of all the neuroendocrine cells in the pancreatic islets and is also seen in adrenal cortical cells, probably due to a closely related protein.

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