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Test · Diagnostics

IHC Olig2

Free home sample collection, physician reviewedDaily , Report 5 DaysReports inBloodSample

Oligodendrocyte transcription factor 2 (OLIG2) is a transcription factor that participates in oligodendrocyte and motor neuron differentiation. During embryogenesis OLIG2 promotes the growth of motor neuron progenitor cells. OLIG2 expression decreases upon further neuronal differentiation. OLIG2 is also involved in oligodendrocyte differentiation where expression remains present in mature glial cells. In gliomas, OLIG2 represses the p53 tumor suppressor pathway, thereby contributing to glioma progression.

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