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Test · Diagnostics

All PCR Panel

Free home sample collection, physician reviewed5-7 DaysReports inBloodSample

Acute lymphoblastic leukaemia (ALL) is mainly a disease of childhood that arises from recurrent genetic alterations that block precursor B- and T-cell differentiation and drive aberrant cell proliferation and survival. Due to the advances in the cytogenetic and molecular characterization of the acute leukaemias in the past two decades, genetic alterations can now be identified in more than 80% of cases of ALL. These genetic lesions influence the prognosis and therapeutic approach used for treatment of ALLs. Chromosomal translocation is the hallmark of leukaemias and acute lymphoblastic leukaemia (ALL) in particular. DNA damage arises from endogenous and exogenous genotoxic factors and lack of complete fidelity in DNA-repair leads to chromosomal translocations. Chromosomal breakpoints tend to occur at transcriptionally active DNA sites and the fusion gene transcripts generally involve genes which frequently encode cell cycle regulators, transcription factors, signal transduction molecules, receptors or immunoglobulin and TCR molecules. Due to the chromosomal translocations and subsequent expression of fusion gene transcripts, the normal functions of the genes are altered.

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