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Test · Diagnostics

TPMT (Thio Purine Methyl Transferase) + NUDT

Free home sample collection, physician reviewed5 - 7 DaysReports inBloodSample

Detection of TPMT genetic variants by genotyping is recommended prior to commencing the treatment of patients with Thiopurine drugs such as Azathioprine, 6-Mercaptopurine and 6-Thioguanine for Acute Lymphoblastic Leukemia & autoimmune disorders like Crohn's disease & Rheumatoid arthritis.TPMT is an enzyme which converts these drugs in the body to an active form. Any genetic defect in this enzyme predisposes patients to a heightened risk of drug-induced bone marrow toxicity due to accumulation of unmetabolised drug. Approximately 0.3% of individuals lack TPMT activity while 11% show reduced activity (variants TPMT*2, 3A & 3C). 89% of people have normal activity (variant TPMT*1).

₹15,000—Members pay ₹14000